Storm success came easy

Osler came to Boston.

When Asperger's Disorder Came Out.

BACKGROUND In 2013, the American Psychiatric Association removed Asperger's Disorder from the DSM, offering instead the new DSM-5 diagnosis: Autism Spectrum Disorder. This change has been hailed the most controversial exclusion from the DSM, yet unlike the 1973 removal of homosexuality from DSM-III, Asperger's disorder has not been demedicalised. Rather, the disorder has simply been reclassifie...

How Human Genetics Came to Sa

S33 June 2016, Vol. 106, No. 6 (Suppl 1) The massive strides made in human genetics in the last 10 years would not have been possible without the diligent and insightful work of the pioneers in human genetics. This is particularly true in South Africa (SA), where a small community of scientists and clinicians have been responsible for the application of scientific/ medical advances into the wid...

Coregulators: from whence came these "master genes".

It is now over a decade since the first nuclear receptor coactivator, SRC-1, was cloned and discovered to be a new type of transcription factor that does not bind DNA, but rather, binds directly or indirectly to nuclear receptors (NRs) to mediate their transcriptional potency. The NR coactivators belong to a class of molecules now termed ‘coregulators’. Employing an ‘operational’ definition, we...

How Networks of Queues Came About

T essay, about work done almost a half century ago, is written as a snippet of autobiography rather than as a technical review of the mathematics of networks of queues. To summarize, interest in jobshop manufacturing led me to a good mathematical subject area. I tried the only technique I knew that seemed applicable to one of the more obvious problems in this area; surprisingly, this technique ...